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KMID : 0545120230330050600
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Journal of Microbiology and Biotechnology
2023 Volume.33 No. 5 p.600 ~ p.606
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Dengue Virus 2 NS2B Targets MAVS and IKKε to Evade the Antiviral Innate Immune Response
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Ying Nie
Dongqing Deng
Lumin Mou
Qizhou Long
Jinzhi Chen
Jiahong Wu
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Abstract
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Dengue virus (DENV) is a widespread arbovirus. To efficiently establish infection, DENV evolves multiple strategies to hijack the host innate immune response. Herein, we examined the inhibitory effects of DENV serotype 2 (DENV2) nonstructural proteins on RIG-I-directed antiviral immune response. We found that DENV2 NS2A, NS2B, NS4A, and NS4B significantly inhibited RIG-I-mediated IFN-β promoter activation. The roles of NS2B in RIG-I-directed antiviral immune response are unknown. Our study further showed that NS2B could dose-dependently suppress RIG-I/MAVS-induced activation of IFN-β promoter. Consistently, NS2B significantly decreased RIG-I- and MAVS-induced transcription of IFNB1, ISG15, and ISG56. Mechanistically, NS2B was found to interact with MAVS and IKKε to impair RIG-I-directed antiviral response. Our findings demonstrated a previously uncharacterized function of NS2B in RIG-I-mediated antiviral response, making it a promising drug target for anti-DENV treatments.
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KEYWORD
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DENV2, NS2B, MAVS, IKKε, Innate immune response
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